Our group is interested in elucidating how the mammalian (epi)genome is maintained throughout cell divisions and how the epigenetic information is translated into spatial chromatin structure and activity during differentiation, reprogramming and disease.
We make use of a variety of biochemical, molecular and cell biological methods with particular emphasis on advanced live-cell and super-resolution fluorescence microscopy.
In the course of our work, we develop new approaches to deliver macromolecules to living cells and establish tools including nanobodies to visualize subcellular structures and cell cycle progression in real time.
Post from May 25: Do you know what the Feulgen reaction is?
Our latest work on DNA dynamics from loops to chromosomes is out in the special issue " The Centennial of the Feulgen Reaction - Imaging the Genome" Springer. Check it out: https://link.springer.com/article/10.1007/s00418-024-02285-x
Post from April 8: Detection of small genomic elements in cells (3D) has always been a challenge.
Here we present an optimised labelling method (NOVA FISH) to detect small DNA segments and map their spatial organisation. Look here: https://www.biorxiv.org/content/10.1101/2024.03.15.583980v1
