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Cell Biology of the (Epi)Genome

Our group is interested in elucidating how the mammalian (epi)genome is maintained throughout cell divisions and how the epigenetic information is translated into spatial chromatin structure and activity during differentiation, reprogramming and disease.
We make use of a variety of biochemical, molecular and cell biological methods with particular emphasis on advanced live-cell and super-resolution fluorescence microscopy. In the course of our work, we develop new approaches to deliver macromolecules to living cells and establish tools including nanobodies to visualize subcellular structures and cell cycle progression in real time.

The interactive 3D viewer displays the chromatin structure (76 chromosomes, HeLa cells) resulting from a modified random loop model with about 104,000 beads.

Check it out: http://sim.bio.tu-darmstadt.de/sim/viewer_3d/dna/


Cardoso Lab  •  Technische Universität Darmstadt  •  Germany


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