Our group is interested in elucidating how the mammalian (epi)genome is maintained throughout cell divisions and how the epigenetic information is translated into spatial chromatin structure and activity during differentiation, reprogramming and disease.
We make use of a variety of biochemical, molecular and cell biological methods with particular emphasis on advanced live-cell and super-resolution fluorescence microscopy.
In the course of our work, we develop new approaches to deliver macromolecules to living cells and establish tools including nanobodies to visualize subcellular structures and cell cycle progression in real time.
Post from Sep 10 : Our recent paper is out. In it, we address how transfection using microwave poration enables efficient delivery of diverse molecules into mammalian cells with minimal impact. This is a promising technology for transfection. https://doi.org/10.1038/s41598-024-71401-7
Post from Sep 5 : Check out our latest work on how histone variant mH2A1 regulates DNA replication of inactive X chromosome.. catalytic Point mutation prediction using alphafold was a key finding https://doi.org/10.1093/nar/gkae734
